刘杨.Effects of probiotics, prebiotics, and synbiotics on calcium homeostasis and bone health with aging: a systematic review
Effects of probiotics, prebiotics, and synbiotics on calcium homeostasis and bone health with aging: a systematic review
Yang Liu, Yajie Zhao, Yajun Yang, Zhiwen Wang
Background: Calcium homeostasis and bone health is an increasing concern for middle-aged and elderly people. Many studies have explored the positive effect of probiotics, prebiotics or synbiotics on serum calcium and bone mineral density (BMD) or other parameters related to bone health. However, the participants, the species, doses and duration of interventions, outcomes and measurements varied among these studies.
Aims: To systematically evaluate the effect of probiotics, prebiotics or synbiotics, on maintaining calcium homeostasis and improving bone health in middle-aged and elderly people.
Methods: We identified studies in Cochrane Library, Embase, PubMed, Web of Science (WOS), CINAHL, China National Knowledge Infrastructure (CNKI), and Wanfang and articles in English and Chinese published from inception up to 10 January 2019. Randomized controlled trials involving probiotics, prebiotics or synbiotics for middle-aged or older adults were employed for meta-analysis by using RevMan 5.3, and heterogeneity and risk of bias assessment were performed.
Results: a total of eight studies, involving 564 participants, were included. Probiotics, prebiotics or synbiotics supplementation was proved to be able to significantly elevate serum calcium levels (0.52 mg/dL, 95% CI [0.38, 0.66]), heterogeneity:p = 0.13, I2= 44%). While the results of meta-analysis failed to support the effects of this supplementation on the parameters related to bone health in middle-aged and elderly people, including BMD, parathyroid hormone (PTH), osteocalcin (OC), and alkaline phosphatase (ALP).
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